In the ever-evolving world of aesthetic medicine, a new class of regenerative bio-stimulants is taking center stage: polynucleotides. Moving beyond simple filler or relaxant strategies, polynucleotides work at a cellular level to rejuvenate and repair skin from within.
In the realm of biochemistry, polynucleotides are defined as long, chain-like polymers composed of nucleotide monomers, serving as the foundational molecules of DNA and RNA—the very blueprints of life. In aesthetic medicine, the polynucleotides used are not synthetic but are instead derived from highly purified natural sources, most commonly salmon DNA. The reason for this is profound scientific synergy: salmon DNA shares an exceptionally high degree of biocompatibility with human DNA. This means when introduced into the human dermis, it is recognized as a friendly, bioactive substance rather than a foreign invader, minimizing risk and maximizing efficacy.
Polynucleotides activate fibroblasts to stimulate the natural production of collagen, elastin, and hyaluronic acid—effectively rebuilding skin from within and improving structural integrity.
Their high molecular weight allows them to attract and bind moisture, resulting in significantly improved skin hydration, plumpness, and a reduction in dry fine lines.
By promoting new collagen and elastin formation, polynucleotides increase skin density and tightness, restoring a more lifted and resilient appearance.
They possess natural anti-inflammatory properties, making them ideal for sensitive skin and delicate areas like the eye contour, reducing redness and reinforcing the skin barrier.
Treatments lead to smoother texture, refined pores, and a more even complexion with restored luminosity—combating dullness for a revitalized glow.
Often used post-laser or energy-based procedures, polynucleotides help accelerate healing, minimize downtime, and improve overall outcomes.
Polynucleotides are effective for key areas on the face and body where skin is most prone to sagging, weakening, and fatigue due to aging and lifestyle factors. These include the face, neck, décolleté, hands, inner arms, jawline, cheeks, and abdomen. Additionally, polynucleotide treatments are increasingly sought for the under-eye area.
In fact, they are one of the few skin treatments suitable for delicate zones such as under the eyes, around the lips, and the thin skin of the forehead.
Clinical research and practical applications confirm that polynucleotide injectables are generally well-tolerated, thanks to their high biocompatibility and ability to integrate naturally with human tissue. Adverse effects are typically minimal and limited to temporary redness, swelling, or mild bruising at the injection site.
In medically trained, experienced hands polynucleotides are considered safe. However, the safety profile of polynucleotides treatments is closely linked to the quality of the product used. Not all formulations are manufactured with the same level of purity or consistency, which makes product selection critical. Choosing a trusted, medical-grade option such as PNPURE™ ensures that the polynucleotides are sourced and purified under strict standards, minimizing risks while maximizing therapeutic effectiveness. Click here to get a PNPURE™ quote and stay up to date on the latest offers.
For those seeking the exceptional rejuvenating benefits of polynucleotides, we highly recommend the PNPURE™. Sourced from premium Pacific salmon DNA and purified with advanced PUNEXT™ technology, PNPURE™ offers superior biocompatibility and a high concentration of large-molecular-weight polynucleotides for deep, lasting skin restoration.
For patients seeking comprehensive improvement in texture, elasticity, and hydration, PNPURE™ NeoSkin serves as an advanced skin booster. With its high concentration of polynucleotides (25 mg/ml) and large molecular weight structure (1260–1570 kDa), NeoSkin provides deep dermal repair and long-lasting hydration. Clinical applications include overall tone correction, barrier reinforcement, and enhanced post-procedure recovery.
The periocular area is one of the most challenging regions in aesthetic medicine due to its thin skin and sensitivity. PNPURE™ NeoEye is formulated specifically for this region, combining PN with hyaluronic acid, amino acids, and carnosine to address dark circles, fine lines, and loss of elasticity. When applied as a focused pn product, NeoEye reduces visible fatigue, improves brightness, and restores firmness while minimizing irritation in this delicate zone.
Whether your clients require comprehensive facial rejuvenation or specialized periocular restoration, PNPURE™ series are engineered to meet the highest standards of efficacy, safety, and reliability. Please contact us to learn more about PNPURE™ polynucleotide products.
