Hello everyone, what I want to talk about today is: how to use botulinum toxin to treat underarm hyperhidrosis.
Hyperhidrosis is a common skin disease with an incidence rate of 0.6% to 1.0%. The clinical manifestations of patients are excessive sweating, which is different from ordinary people. It usually involves areas with many sweat glands such as palms and soles, armpits, face, and back.
1. Principles of treatment
The main clinical use of botulinum toxin is to reduce muscle contraction force and to treat some muscle-related diseases, such as strabismus, muscle spasm, dynamic wrinkles, etc. In addition, botulinum toxin has the effect of inhibiting the secretion of various glands.Sweat glands are controlled by sympathetic postganglionic fibers. After the C-terminus of the heavy chain of botulinum toxin binds to nerve cell receptors, its light chain enters the cell, and the fusion protein is endo-cleaved. In this way, postganglionic cholinergic nerve fiber synapses can be inhibited The release of acetylcholine from the anterior membrane vesicles inhibits nerve signal transduction, thereby inhibiting the secretion of sweat glands and achieving the purpose of treating hyperhidrosis.
2.injection dose
The usual dose of botulinum toxin injection for the treatment of axillary hyperhidrosis is 50 U per side.
3. Injection method
Botulinum toxin injection usually uses a syringe with a needle, the specifications are 0.3ml, 1.0ml, 5ml, with a 30G or 27G thinner needle. For the axillary injection interval, a fixed distance of 2cm and 1.5cm is often used. The injection level of botulinum toxin in the treatment of hyperhidrosis is generally shallow. In most cases, it is injected intradermally, and some are injected into the subepidermal layer and subcutaneous tissue junction.
It is an effective and safe method for the treatment of hyperhidrosis, but botulinum toxin injection has disadvantages such as the need for repeated injections and injection pain, which need to be gradually solved in future research.
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